Lecture abstract: Hyperbaric oxygen therapy (HBOT) is a dual-component therapy composed of increased barometric pressure and hyperoxia that have primary epigenetic effects. HBOT affects the expression and suppression of over 40% of the protein-coding genes in human chromosomes. Amongst the largest clusters of genes expressed and suppressed are the anti-inflammatory and pro-inflammatory genes, respectively. This talk will briefly review the definition and mechanisms of action of HBOT, the rationale for treating spike protein-induced diseases with HBOT, the literature on HBOT’s effects on inflammation/immune system dysfunction, and the literature on applying HBOT to spike-induced diseases. It will conclude with recommendations for treating spike-induced diseases with HBOT.